Dilatation, compensatory growth, or both after pneumonectomy during childhood and adolescence
نویسندگان
چکیده
منابع مشابه
Compensatory Lung Growth After Pneumonectomy
Pneumonectomy, the surgical removal of a lung, elicits a number of anatomical changes within the thoracic cavity that augments the diffusion capacity of the remaining lung. Pneumonectomy directs the entire cardiac output into the remaining lung and creates an empty hemithorax that results in a shift of the mediastinum toward the vacated thoracic compartment. In a number of experimental animal m...
متن کاملGrowth factor activity in the lung during compensatory growth after pneumonectomy: evidence of a role for IGF-1.
Unilateral pneumonectomy in rats causes compensatory growth of the remaining lung. During this growth, there are large increases in the cell numbers and in the rates of collagen and non-collagen protein production. We examined possible mechanisms by which these changes might occur. Assessment of the effect of bronchoalveolar lavage (BAL) fluid on fibroblasts in vitro demonstrated the presence o...
متن کاملTime course of and stimuli to compensatory growth of the lung after pneumonectomy.
Left pneumonectomy in the mature rat led to an increase of [3Ha1 thymidine incorporation into DNA of the remaining lung in the first 3 postoperative days, and resulted in a subsequent 38% increase of lung weight and 41% increase of lung tissue volume measured 1 wk after surgery. Despite these early changes, total lung volume (TLV) did not increase until the 2nd postoperative wk, reaching values...
متن کاملNeoalveolarisation contributes to compensatory lung growth following pneumonectomy in mice.
Regeneration of the gas exchange area by induction of neoalveolarisation would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. The question of whether new alveoli are added to the residual lung after pneumonectomy in mice was a...
متن کاملNeoalveolarization contributes to compensatory lung growth following pneumonectomy in mice
Regeneration of gas exchange area by induction of neoalveolarization would greatly improve therapeutic options in destructive pulmonary diseases. Unilateral pneumonectomy is an established model to remove defined portions of gas exchange area and study mechanisms of compensatory lung growth. We addressed the question whether new alveoli are added to the residual lung after pneumonectomy in mice...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1987
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)36386-x